Researchers at MIT have developed a scalable method for producing nanoparticles that can target cancer cells, offering new hope for improved cancer treatment outcomes.
MIT researchers have developed a way to rapidly manufacture nanoparticles that can be used for targeted delivery of cancer drugs and other therapeutics. The new method, which uses a microfluidic device, allows for the production of large quantities of ‘nanoparticles in just a few minutes.’
Nanoparticle technology involves the creation and application of particles measuring between 1-100 nanometers in size.
These tiny structures have unique properties, such as increased surface area and reactivity, making them suitable for various industries like medicine, electronics, and energy.
Researchers are exploring nanoparticles for targeted drug delivery, cancer treatment, and diagnostic imaging.
Additionally, nanoparticles can enhance solar cell efficiency and improve battery performance.
As the field continues to advance, nanotechnology is poised to revolutionize numerous sectors with its potential for innovation and discovery.
The nanoparticles are coated with therapeutic agents such as cytokines and can be designed to target specific cancer cells. In mouse models of ovarian cancer, these particles have shown promise in delaying tumor growth and even inducing cures.
Cancer treatment has witnessed significant progress in recent years.
Targeted therapies, immunotherapies, and precision medicine have improved patient outcomes.
According to the American Cancer Society, cancer death rates have declined by 27% since 2001.
New treatments like CAR-T cell therapy and checkpoint inhibitors have shown promise in treating various types of cancer.
Researchers are also exploring the use of artificial intelligence and genomics to personalize treatment plans.
Scaling Up Nanoparticle Production
The new method is an improvement over existing techniques, which were limited by their manufacturing complexity and maximum scale of production. The microfluidic device used in the study allows for the sequential addition of polymer layers, eliminating the need for manual mixing and streamlining production.
This approach also integrates good manufacturing practice (GMP)-compliant processes, making it easier to produce nanoparticles on a large scale. The researchers estimate that this method could enable the production of more than enough ‘particles for clinical trials and patient use.’
Scalable nanoparticle production involves developing methods to manufacture nanoparticles on a large scale while maintaining control over their size, shape, and composition.
This process is crucial for various applications, including medicine, electronics, and energy storage.
Techniques such as microfluidics, spray drying, and continuous flow processing have shown promise in achieving scalability.
Researchers are also exploring the use of 3D printing and robotic manufacturing to further enhance production efficiency.
Potential Applications
The technology has potential applications in various types of cancer, including glioblastoma. While further research is needed, the researchers are optimistic about the potential of their discovery to improve cancer treatment outcomes.
The study’s findings have been published in Advanced Functional Materials, and the researchers have filed for a patent on the technology. They are now working with MIT’s Deshpande Center for Technological Innovation to potentially form a company to commercialize the technology.
